2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenosine Receptor

Adenosine Receptor

P1 receptor

Adenosine Receptor

Related Products

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Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Isoform Specific Products:

Adenosine Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0140R
    Aminophylline (Standard)
    		Antagonist
    Aminophylline (Standard) is the analytical standard of Aminophylline. This product is intended for research and analytical applications. Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research.
    Aminophylline (Standard)
  • HY-B0128R
    Diphylline (Standard)
    		Antagonist
    Diphylline (Standard) is the analytical standard of Diphylline. This product is intended for research and analytical applications. Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema.
    Diphylline (Standard)
  • HY-111129
    CP-66713
    		Antagonist
    CP-66713 is a selective adenosine A2 receptor antagonist, with Ki of 22 nM. CP-66713 inhibits induction of long-term potentiation of evoked synaptic potentials. CP-66713 can be used in the study of neurological diseases.
    CP-66713
  • HY-B1505A
    Acefylline piperazine
    		Antagonist
    Acefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research.
    Acefylline piperazine
  • HY-164621
    A3AR antagonist 5
    		Antagonist 98.17%
    A3AR antagonist 5 (Compound 16) is a selective antagonist for human adenosine A3 receptor with an affinity pC of 4.542 μM.
    A3AR antagonist 5
  • HY-118232
    VUF8504
    		Antagonist
    VUF-8504 is a potent and selective adenosine A3 receptor antagonist with Ki value of 0.017, 14 nM for human A3, A1, respectively.
    VUF8504
  • HY-10081R
    GS-6201 (Standard)
    		Antagonist
    GS-6201 (Standard) is the analytical standard of GS-6201 (HY-10081). This product is intended for research and analytical applications. GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM). GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse. GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice.
    GS-6201 (Standard)
  • HY-103166R
    PSB-603 (Standard)
    		Antagonist
    PSB-603 (Standard) is the analytical standard of PSB-603 (HY-103166). This product is intended for research and analytical applications. PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.
    PSB-603 (Standard)
  • HY-105275AR
    FK 453 (Standard)
    		Antagonist
    FK 453 (Standard) is the analytical standard of FK 453 (HY-105275A). This product is intended for research and analytical applications. FK 453 (compound 1d) is a potent and selective adenosine A1 receptor antagonist with an IC50 value of 17.2 nM.
    FK 453 (Standard)
  • HY-103165R
    PSB-0788 (Standard)
    		Antagonist
    PSB-0788 (Standard) is the analytical standard of PSB-0788 (HY-103165). This product is intended for research and analytical applications. PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases.
    PSB-0788 (Standard)
  • HY-10965R
    Rolofylline (Standard)
    		Antagonist
    Rolofylline (Standard) is the analytical standard of Rolofylline. This product is intended for research and analytical applications. Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
    Rolofylline (Standard)
  • HY-121453
    Bamifylline hydrochloride
    		Antagonist
    Bamifylline hydrochloride is a drug in the chemical class of xanthine that acts as a selective adenosine A1 receptor antagonist.
    Bamifylline hydrochloride
  • HY-103168
    XCC
    		Antagonist
    XCC, 1,3,8-substituted xanthine derivative, is an adenosine receptor antagonist with Ki of 1.905 μM[1].
    XCC
  • HY-103169R
    SCH442416 (Standard)
    		Antagonist
    SCH442416 (Standard) is the analytical standard of SCH442416. This product is intended for research and analytical applications. SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain.
    SCH442416 (Standard)
  • HY-U00341
    ST4206
    		Antagonist
    ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research.
    ST4206
  • HY-U00321
    A2B receptor antagonist 1
    		Antagonist
    A2B receptor antagonist 1 is a potent A2B adenosine receptor antagonist extracted from patent WO 2009157938 A1 EXAMPLE 9B.
    A2B receptor antagonist 1
  • HY-U00189
    Sch412348
    		Antagonist
    Sch412348 is a potent competitive antagonist of the human adenosine A2A receptor (Ki=0.6 nM) and has >1000-fold selectivity over all other adenosine receptors.
    Sch412348
  • HY-U00143
    N-0861 racemate
    		Antagonist
    N-0861 racemate is the racemate of N-0861. N-0861 is a selective adenosine A1 receptor antagonist.
    N-0861 racemate
Cat. No. Product Name / Synonyms Application Reactivity
Adenosine Receptor Isoform Comparison

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